paclitaxel 99.5%

from Taxus brevifolia, ≥99.5% (HPLC), powder
CAS号: 33069-62-4
C47H51NO14
853.91
Biological source: from Taxus brevifolia 
Assay ≥95% (HPLC) 
Form :powder 
Color :white 
Mp :213 °C (dec.)(lit.) 
Solubility DMSO: soluble50 mg/mL (can be stored frozen for several months) 
Caution
Paclitaxel undergoes transesterification in methanol and hydrolyzes in aqueous solutions.
Biochem/physiol Actions
Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase. The microtubule damage induces apoptosis through a JNK-dependent pathway followed by a JNK-independent pathway, perhaps related to the activation of protein kinase A (PKA) or of Raf-1 kinase, resulting in phosphorylation of Bcl-2. A major metabolite via CYP2CB is 6α-hydroxypaclitaxel (6α-OHP).